TypeA

  • Removed all motifs where both similar drugs bind to the target.
  • 30,231 motifs were originally identified, now 27,499 (-2,732).

TypeB

  • Removed motifs where the drug binds to both targets.
  • 22,864 motifs were orignally identified, now 19,185 (-3,679).

TypeC

  • Removed motifs where protein(1) inv_in disease(2) or protein(2) inv_in disease(1).
  • 70,866 motifs were orignally identified in the dataset, now 70,715 (-151).
  • Tried: Remove motifs where the target connects to protein(2), this did not take into account that some links are has_similar_sequence/structure and not is_a. 200 (-70,515).
  • Removed motifs with target is_a protein2, made no difference to total.

Ondex

  • Selecting a node with a certain id in Ondex?
  • Too hard when there is 500k nodes
  • Search doesn’t work
  • Ondex Console: how to use this??? -> help is unavailable surprisingly.