Posts tagged Paper

References

Aug 18th

Posted by Andrew in Paper

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References are now all accounted for and are listed on the references page.

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Progress

Jul 31st

Posted by Andrew in Paper

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Progress page added: [Progress]

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Writing Plan

Jul 23rd

Posted by Andrew in Paper

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Latest version: [File]

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Motif Examples

Jul 12th

Posted by Andrew in Paper

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Looked at results for some good “known” off-label for each type of motif to write about in the paper.

  • MotifA - Lenalidomide <–> Thalidomide –> TNF [Multiple Myeloma among other things]
  • MotifB - Topiramate
  • MotifC - Isradipine [Heart/Blood Pressure and Parkinson's Disease/ ~Paralysis]

Ideas for the scoring section of the paper:

  • Check the values such as Tanimoto, BLAST and G-Sesame known motifs (i.e. Chlorpromazine)
  • Is there any differentation between a known motif and a random unsignificant motif
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Jun 3rd

Posted by Andrew in Paper

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Researching interesting papers to start the introduction of the paper:

Butcher, E.C., Berg, E.L. and Kunkel, E.J. (2004) Systems biology in drug discovery. Nature Biotechnology. 22:1253-1259. [Link]
Drews, J. (2000) Drug Discovery: A Historical Perspective. Science. 287(5460):1960-1964. [Link]
Kitano, H. (2002) Computational systems biology. Nature. 420:206-210. [Link]

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